Anticancer plants Properties and Application

Asian Pac J Cancer Prev 17:4367–4375 Abdulkareem IH (2013) Aetio-
pathogenesis of breast cancer. ... Shati AA (2016) Antiproliferative activity of the
methanolic extract of Withania somnifera leaves from Faifa mountains, southwest
Saudi ...

Anticancer plants  Properties and Application

Author: Mohd Sayeed Akhtar

Publisher: Springer

ISBN: 981108548X

Page: 582

View: 126

Cancer is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though, several synthetic medicines are useful in treating cancer, they are inefficient and unsafe. However, plants have proved to be useful in cancer cure. Moreover, natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types. The anticancer plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays, several well-known anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences, the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence, there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities. Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis. We acknowledge the publisher, Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support, and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics, pharmaceuticals, nutraceuticals and medical practitioners.

Science of Ashwagandha Preventive and Therapeutic Potentials

Alcoholic extract of Withania somnifera leaves (i-Extact) and its different
components (Withaferin A, Withanone, Withanolide A) showed an effective dose
dependent antiproliferative activity against ratglioma cell line, C6 and human
glioma cell ...

Science of Ashwagandha  Preventive and Therapeutic Potentials

Author: Sunil C. Kaul

Publisher: Springer

ISBN: 3319591924

Page: 508

View: 194

Rapidly increasing aging population and environmental stressors are the two main global concerns of increasing incidence of a variety of pathologies in the modern society. The complex etiologies and pathologies cause major challenges to disease treatment. On the other hand, several herbs are known for their health-caring and disease-curing activities. Ashwagandha, a popular herb in Indian traditional home medicine, Ayurveda, has gathered increasing recognition in recent years when the chemically synthesized drugs for single target therapies showed limited success and adverse toxic effects. Ashwagandha is known as a powerful adaptogen and trusted to enhance function of the brain, reproductive system, cell-mediated immunity and increase the body's defense against disease, and possess anti-inflammatory, anticancer and anti-arthritic activities. In this book, for the first time, we provide a complete portrait on scientific understanding of the effects of Ashwagandha and its active principles for a variety of preventive and therapeutic activities.

Ethnobotany

Anticancer activities of Withania somnifera: current research, formulations, and
future perspectives. Pharm. Biol. ... Anti-proliferative activities of selected Chinese
medicinal herbs against human cancer cell lines. Phytopharmacology 4: ...

Ethnobotany

Author: José L. Martinez

Publisher: CRC Press

ISBN: 0429841795

Page: 288

View: 315

Ethnobotany includes the traditional use of plants in different fields like medicine and agriculture. This book incorporates important studies based on ethnobotany of different geographic zones. The book covers medicinaland aromatic plants, ethnopharmacology, bioactive molecules, plants used in cancer, hypertension, disorders of the central nervous system, and also as antipsoriatic, antibacterial, antioxidant, antiurolithiatic. The book will be useful for a diverse group of readers including plant scientists, pharmacologists, clinicians, herbalists, natural therapy experts, chemists, microbiologists, NGOs and those who are interested in traditional therapies.

Biodiversity and Biomedicine

Isolation and characterization of a Phaseolus vulgaris trypsin inhibitor with
antiproliferative activity on leukemia and ... Cytotoxic and apoptotic activities of
extracts of Withania somnifera and Tinospora cordifolia in human breast cancer
cells.

Biodiversity and Biomedicine

Author: Munir Ozturk

Publisher: Academic Press

ISBN: 0128223707

Page: 608

View: 292

Biodiversity and Biomedicine: Our Future provides a new outlook on Earth’s animal, plant, and fungi species as vital sources for human health treatments. While there are over 10 million various species on the planet, only 2 million have been discovered and named. This book identifies modern ways to incorporate Earth’s species into biomedical practices and emphasizes the need for biodiversity conservation. Written by leading biodiversity and biomedical experts, the book begins with new insights on the benefits of biologically active compounds found in fungi and plants, including a chapter on the use of wild fruits as a treatment option. The book goes on to discuss the roles of animals, such as amphibians and reptiles, and how the threatened presence of these species must be reversed to conserve biodiversity. It also discusses marine organisms, including plants, animals, and microbes, as essential in contributing to human health. Biodiversity and Biomedicine: Our Future is a vital source for researchers and practitioners specializing in biodiversity and conservation studies. Students in natural medicine and biological conservation will also find this useful to learn of the world’s most bio-rich communities and the molecular diversity of various species. Presents new developments in documenting and identifying species for biodiversity conservation and ethical considerations for biodiversity research Examines biodiversity as an irreplaceable resource for biomedical breakthroughs using available species for medical research Discusses challenges and opportunities for biodiversity protection and research in biosphere reserves

The Enzymes

[3] P.U. Devi, Withania somnifera Dunal (Ashwagandha): potential plant source of
a promising drug for cancer ... A-related steroids from Withania aristata exhibit
potent antiproliferative activity by inducing apoptosis in human tumor cells, Eur.

The Enzymes

Author:

Publisher: Academic Press

ISBN: 0128038772

Page: 276

View: 593

Volume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of the Enzyme series was on the topic of Natural Products and Cancer Signaling Targets: Isoprenoids, Polyphenols and Flavonoids), will highlight the significant advance made in the field in elucidating mechanisms of anticancer effect of the major phytochemicals. Contributions from leading authorities Informs and updates on all the latest developments in the field

Chimie Pure Et Appliqu e

... and structure - activity studies of simplified analogues of aplysiatoxin with
antiproliferative activity like bryostatin - 1 1341 ... arena 1543 WITHANIA
SOMNIFERA Antiproliferative withanolides from the Solanaceae : A structure -
activity study ...

Chimie Pure Et Appliqu  e

Author:

Publisher:

ISBN:

Page:

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Medicinal Aromatic Plants Abstracts

... India ) Remedial Wound - healing assay - guided fractionation of a antioxidant
action of Withania somnifera of restraint ... hepati genic effects at lower
concentrations and antiproliferative gynecological and cardiovascular diseases
in China .

Medicinal   Aromatic Plants Abstracts

Author:

Publisher:

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Page:

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Herbal Drugs as Therapeutic Agents

Withaferin A exhibited potent antiproliferative activity against pancreatic cancer
cells in vitro (with IC50 s of 1.24, 2.93 and 2.78 μM) in pancreatic cancer cell ...
Withaferin A: a Potential Anticancer Withanolide from Withania somnifera (L.)
Dun.

Herbal Drugs as Therapeutic Agents

Author: Amritpal Singh

Publisher: CRC Press

ISBN: 1466598603

Page: 232

View: 730

Phytochemicals are the mainstay of therapeutics of herbal or botanical medicine. Research on phytomolecules is conducted worldwide and several have been screened for clinical trials. This includes several promising anticancer phytomolectules, such as withaferin-a and camphothecin. This book provides a scientific understanding of the mode of action of these molecules. It targets only those phytohemicals and herbal extracts that are subjects of recent pharmacological investigations. Chapters such as industrial crops for steroid manufacturing and anticancer and cytotoxic potential of sesquiterpenoids add special flavour to the book, making readers eager to learn more about the commercial viability of phytochemical and herbal extracts.

Herbs and Natural Supplements Inkling

Protective effect of Withania somnifera dunal root extract against protracted social
isolation induced behavior in rats. Indian J Physiol ... Khan B et al. Augmentation
and proliferation of T lymphocytes and Th-1 cytokines by Withania somnifera in
stressed mice. ... Khanam S, Devi K. Antimutagenic activity of Ashwagandha.

Herbs and Natural Supplements Inkling

Author: Lesley Braun

Publisher: Elsevier Health Sciences

ISBN: 0729579107

Page: 900

View: 210

A must-have health companion for herbalists, naturopaths, complementary medicine practitioners and students Herbs and Natural Supplements, 3rd Edition: An evidence-based guide presents evidence-based information on the 130 most popular herbs, nutrients and food supplements used across Australia and New Zealand. This exhaustive textbook is organised alphabetically by each herb or nutrient’s common name. Herbs and nutrients are then accompanied by critical information such as daily intake, main actions and indications, adverse reactions, contraindications and precautions, safety in pregnancy and more. This new edition of Herbs and Natural Supplements has been expanded with new chapters on pregnancy and wellness. It also features 10 new monographs for Arginine, Dunaliella, Elde, Goji, Pelargonium, Prebiotics, Red Yeast Rice, Rhodioloa, Shatavari and Taurine. • provides current, evidence-based information on herbal, nutritional and food supplements used in Australia and New Zealand • is user-friendly and easily organised by easy-to-find A-Z herbal monographs • appendices offering important additional information for the safe use of herbal and nutritional supplements, including a list of poison information centres, associations, manufacturers and more • offers clear, comprehensive tables including herb/natural supplement - drug interactions • lists the pharmacological actions of all herbs and natural supplements • a glossary of terms relevant to herbs and natural supplements • two comprehensive new chapters: Herbs and Natural Supplements in Pregnancy and Introduction to Wellness • all chapters completely updated and expanded • ten new monographs taking the total to 130 • now also available as an eBook! A code inside Herbs and Natural Supplements, 3rd Edition: An evidence-based guide enables a full text download, allowing you to browse and search electronically, make notes and bookmarks in the electronic files and highlight material

Integrative Oncology

The antitumor effect of Withania somnifera (ashwagandha) was also
demonstrated against the mouse tumor Sarcoma 180 (Devi, Sharada, Solomon,
& Kamath, 1992). Another study assessed the antiproliferative effects of
ashwagandha on ...

Integrative Oncology

Author: Donald I. Abrams

Publisher: Oxford University Press

ISBN: 0199329745

Page: 624

View: 962

More and more people living with and beyond cancer seek integrative interventions to complement their conventional cancer care. This second edition of the highly successful Integrative Oncology provides the reader with the most updated information available with new chapters on Music and Expressive Arts Therapies, Naturopathic Oncology, and an integrative approach to Lung Cancer. Integrative medicine is defined as healing-oriented medicine that takes account of the whole person (body, mind, and spirit) as well as all aspects of lifestyle; it emphasizes the therapeutic relationship and makes use of appropriate therapies, both conventional and alternative. This series grows out of a need to organize and make accessible to clinicians the basic principles of integrative medicine in practical application to common health conditions. Each volume focuses on a particular specialty and features well-recognized and authoritative editors and chapter authors. The text is presented in an easy-to-read format featuring case histories, clinical pearls, and useful tables, with all key information highlighted. Series editor Andrew Weil, MD, is Professor and Director of the Arizona Center for Integrative Medicine at the University of Arizona. Dr. Weil's program was the first such academic program in the U.S., and its stated goal is "to combine the best ideas and practices of conventional and alternative medicine into cost effective treatments without embracing alternative practices uncritically."

Fundamentals of Pharmacognosy and Phytotherapy E Book

Ac ̧ai demonstrates promising potential with regard to antiproliferative activity
and cardioprotection, but further studies ... WITHANIA. SOMNIFERUM. (L.)
DUNAL. Ashwagandha, also known as winter cherry (Solanaceae), is a woody
shrub ...

Fundamentals of Pharmacognosy and Phytotherapy E Book

Author: Michael Heinrich

Publisher: Elsevier Health Sciences

ISBN: 0702052310

Page: 336

View: 876

‘A new classic’ in a new edition! Fully revised and updated throughout New sections on antimicrobials From journal reviews of the previous edition: ‘Drawing on their wealth of experience and knowledge in this field, the authors, who are without doubt among the finest minds in pharmacognosy today, provide useful and fascinating insights into the history, botany, chemistry, phytotherapy and importance of medicinal plants in some of today's health care systems. This is a landmark textbook, which carefully brings together relevant data from numerous sources and provides in an authoritative and exhaustive manner, cutting edge information that is relevant to pharmacists, pharmacognocists, complementary practitioners, doctors and nurses alike.’ The Pharmaceutical Journal ‘This is the first book that I have encountered which combines the compounds and plants found in standard pharmacognosy textbooks, i.e. those used in orthodox Western medicine, with the 'new phytopharmaceuticals' which have become established in Western culture over the last 20 years. The medical establishment in this environment is finally catching up with the practices of the general population and so this book is an excellent choice for those who wish to investigate which of the many plants available have some scientific credence. I shall be adding this book to the Essential Reading list for all of the undergraduate students on our pharmacy degree course and would encourage all those involved in teaching pharmacy students to do the same." P.J. Houghton, Department of Pharmacy, King's College London, Journal of Ethnopharmacology ‘Educated pharmacists no doubt equate Pharmacognosy with hours spent hunched over a microscope identifying vegetable drugs. Many probably consider it as a subject with little importance in a modern pharmacy curriculum. How wrong they are! ... This book is designed to give an overview at an easy-to-understand level of a broad subject area... For students of science and of the healthcare professions it is a useful text and the authors are to be commended for their work.’ Irish Pharmacy Journal From customer reviews: ‘A new classic. This is an excellent publication both for science students and the non scientific who have an interest in phytotherapy. The layout is logical and clearly set out. I love the chemical structural diagrams, and the explanations of even complex sequences are easy to understand with very little jargon. It is encouraging to see pharmacognosy being given a prominent place in a modern textbook, and interesting to see both hand drawings and chemical structures on the same page!’ ‘I can recommend this to anyone who is interested in the science behind herbal products and medicines; especially if you are interested in plants. It's quite simple to follow and very concise! Good for pharmacy students.’ ‘This is an ultimate textbook in this subject and a boon for students of M Pharmacy (Pharmacognosy) as well as undergraduates students of Pharmacy. Besides them, it is really suitable for every course comprising a study of plants and their medicinal use.’ ‘Excellent reference book. As an editor, I instantly found the answers to various questions I had regarding botanical descriptions. And it even answered questions that I hadn't gotten around to asking. Highly recommended!’

Principles and Practice of Phytotherapy

Withania ( Withania somnifera ( L . ) Dunal ) SYNONYMS Middle East , Withania
root is used as a sedative and ... modulates the immune system ; glucocorticoid -
like antiinflammatory and antiproliferative activity ; potentially cytotoxic and ...

Principles and Practice of Phytotherapy

Author: Simon Mills

Publisher:

ISBN:

Page: 643

View: 473

This book provides a detailed, practical and, where possible, research-based rationale for the use of herbal treatments in a wide variety of clinical conditions and problems. Through the filter of current scientific literature, the authors have reevaluated traditional use of herbal remedies and present realistic guidelines for modern practice. A uniquely authoritative guide to applying herbal medicines as serious options for the treatment of some of the most troublesome conditions seen today. In particular, this book gives: * A clear description of the principles and foundations for the practice of phytotherapy * In-depth and detailed profiles of over 45 herbs, reviewing pharmacology, research, and traditional use * Therapeutics for actual disease states, supported by case histories *Coverage of challenging issues such as dosage, safety, and drug-herb interactions

Annual Report

Evaluation of the anti - mycobacterial activity of lead extracts against other
clinically resistant strains of M . tuberculosis and in animal ... a 2 to 5 - fold
increase in the expression of collagen - I ( a marker of osteoblast proliferation
and differentiation ) in calvaria of 21 - day old ... Evaluation of extracts from
Asparagus racemosus and Withania somnifera for neuroprotective properties in
vitro has been initiated ...

Annual Report

Author:

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ISBN:

Page:

View: 654

Alternative Medicine Review

55 Withania somnifera ( Ashwagandha ) : Withania somnifera has been called
Indian ginseng and is considered the pre - eminent adaptogen from the ... In
situations of experimental physical stress in animals , it has shown similar anti -
stress and anabolic activity to Panax ginseng . ... capable of stimulating stem cell
proliferation and improving red blood cell , white blood cell , and platelet
parameters .

Alternative Medicine Review

Author:

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International Journal of Oncology

Lees NP , Harrison KL , Hall CN , Margison GP and Povey AC : Reduced MGMT
activity in human colorectal adenomas is associated ... Mishra LC , Singh BB and
Dagenais S : Scientific basis for the therapeutic use of Withania somnifera (
ashwagandha ) : a review , Altern Med Rev 5 : 334-346 , 2000 . 60. ... Okabe H
and Kouno I : Antiproliferative activity of the main constituents from Phyllanthus
emblica .

International Journal of Oncology

Author:

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ISBN:

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Basic Research and Applications of Mycorrhizae

Part II, Indian J Exp Biol 7: 398-402 Devi PU(1996) Withania somnifera Dunal (
Ashwagandha). Potential plant source of a promising drug for cancer
chemotherapy ... Govindasamy S, Ramamoorthy N, Balasubramanian K (1995) In
vitro studies on the anticancer activity of Bacopa monnieri. ... Planta 67: 432-436
Sahni YP, Srivastava DN (1993) Withania somnifera: an indegenous anti-
ulcergenic drug.

Basic Research and Applications of Mycorrhizae

Author: Gopi K. Podila

Publisher: Anshan Pub

ISBN:

Page: 511

View: 774

Mycorrhizae are a type of fungus formed by the relationship between plant roots and soil, and there is a widespread agreement among botanists and soil scientists that mycorrhizae are beneficial to the health and growth of soil and plants. Research into mycorrhizae has grown enormously in recent years. It is now known that these fungi have numerous properties and functions - they promote plant growth, maintain plant and soil health, provide protection against root diseases, they assist production using reduced fertilizer and pesticides, they effect soil structure, nutrient acquisition, root length and root structure. Mycorrhizae have many useful modern practical applications - the re-vegetation of landscapes, golf courses, contaminated soils, the prevention and retardation of leaf dehydration, the maintenance of soil and plant biodiversity - to name but a few. The editors of this book have produced a valuable collection of specialised contemporary information describing state of the art and modern protocols in mycorrhizal research, compiled and presented in one authoritative volume. It will be a valued reference work for botanists, microbiologists, agricultural and soil scientists.

Biochemical Medicine and Metabolic Biology

Effect of Withania Somnifera on Glycosaminoglycan Synthesis in Carrageenin -
Induced Air Pouch Granuloma V . HAZEENA BEGUM AND J . SADIQUE ... The
proliferative phase of granuloma is more sensitive to anti - rheumatic drugs .

Biochemical Medicine and Metabolic Biology

Author:

Publisher:

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View: 931