Genomics of Pattern Recognition Receptors

7 Structural Genomic Variation in NOD-Like Receptors and Cancer . ... 7.1
Structural Genomic Variation in NOD2 and Colorectal Cancer . ... 8 Structural
Genomic Variation in Pattern Recognition Receptors and Cardiovascular
Diseases .

Genomics of Pattern Recognition Receptors

Author: Anton G. Kutikhin

Publisher: Springer Science & Business Media

ISBN: 3034806884

Page: 185

View: 456

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

Essentials of Genomic and Personalized Medicine

... 314 Patent ductus arteriosus, 393 Patenting genes/genomes, 217 public health
genomics, 248 genomic technology, 248 Pathogen-associated molecular
patterns (PAMPs) see Pathogen recognition receptors Pathogen–host
interactions, ...

Essentials of Genomic and Personalized Medicine

Author: Geoffrey S. Ginsburg

Publisher: Academic Press

ISBN: 9780080958118

Page: 850

View: 453

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. * Full color throughout * Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice * Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Genomic and Personalized Medicine

ImmuneresponseA * Pattern recognition receptors * Figure 93.1 Different classes
of pathogens trigger specific pattern-recognition receptors (PRRs) differentially
expressed on Microbe B Microbe C Immune response C Immune response B ...

Genomic and Personalized Medicine

Author:

Publisher: Academic Press

ISBN: 0123822289

Page: 1350

View: 401

Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Pattern Recognition Receptors Advances in Research and Application 2013 Edition

ScholarlyBrief. Medical University of SOuth Carolina, Charleston: Toll-like
Receptor-Induced Inflammatory Cytokines are Suppressed ... TLR4-induced
inflammatory cytokines. Novel transgenic mice with genomic 'knock-in' of a
regulator of G ...

Pattern Recognition Receptors   Advances in Research and Application  2013 Edition

Author:

Publisher: ScholarlyEditions

ISBN: 1481691031

Page: 181

View: 794

Pattern Recognition Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Pattern Recognition Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pattern Recognition Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Functional Genomics in Aquaculture

The nonself recognition is activated by pattern recognition proteins (PRP) on
microbial surfaces that are recognized by pattern recognition receptors. One such
pattern recognition receptor is Toll-like receptors (TLR), a class of
transmembrane ...

Functional Genomics in Aquaculture

Author: Marco Saroglia

Publisher: John Wiley & Sons

ISBN: 1118350014

Page: 416

View: 338

Genomics has revolutionized biological research over the course of the last two decades. Genome maps of key agricultural species have offered increased understanding of the structure, organization, and evolution of animal genomes. Building upon this foundation, researchers are now emphasizing research on genome function. Published with the World Aquaculture Society, Functional Genomics in Aquaculture looks at the advances in this field as they directly relate to key traits and species in aquaculture production. Functional Genomics in Aquaculture opens with two chapters that provide a useful general introduction to the field of functional genomics. The second section of the book focuses on key production traits such as growth, development, reproduction, nutrition, and physiological response to stress and diseases. The final five chapters focus on a variety of key aquaculture species. Examples looking at our understanding of the functional genomes of salmonids, Mediterranean sea bass, Atlantic cod, catfish, shrimp, and molluscs, are included in the book. Providing valuable insights and discoveries into the functional genomes of finfish and shellfish species, Functional Genomics in Aquaculture, will be an invaluable resource to researchers and professionals in aquaculture, genetics, and animal science.

Decoding the Genomic Control of Immune Reactions

... for Functional and Applied Genomics and CRCfor Chronic Inflammatory
Diseases, Institute for Molecular Bioscience, ... the constitutive expression of a
wide range of myeloid-specific genes, including various pattern recognition
receptors, ...

Decoding the Genomic Control of Immune Reactions

Author: Gregory R. Bock

Publisher: John Wiley & Sons

ISBN: 9780470062111

Page: 232

View: 169

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance? Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues? Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses? Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

Annual Review of Genomics and Human Genetics

conducted in a candidate region (e.g., identified through linkage analysis) to
narrow the signal in a locus down to one gene from the 5–50 genes contained
within a genomic locus TRAF6. ` Innate immunity pattern-recognition receptors
and ...

Annual Review of Genomics and Human Genetics

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The Downy Mildews Genetics Molecular Biology and Control

PAMPs and effectors are recognized directly or indirectly by the pattern
recognition receptors at the cell surface including receptor-like kinases and
receptor-like proteins, and/or by nucleotide binding site—leucine rich repeat
proteins within the ...

The Downy Mildews   Genetics  Molecular Biology and Control

Author: Aleš Lebeda

Publisher: Springer Science & Business Media

ISBN: 1402089732

Page: 206

View: 656

Knowledge of downy mildew pathogens and diseases has increased significantly in taxonomy, phylogeny, genetics, molecular biology, host-parasite interactions, ecology, epidemiology and control. The opportunity to update comprehensively the major advances in these areas was created by the 2nd International Symposium on Downy Mildews held in July 2007 at Olomouc (Czech Republic). Keynote contributions from this meeting are published here in 14 chapters that provide the most authoritative and recent analysis of these biotrophic plant pathogens and their interactions with plants. It will be an invaluable resource to students and researchers in plant pathology, mycology, taxonomy, plant biology and crop protection.

Mechanisms of Lymphocyte Activation and Immune Regulation X

PAMPs are recognized by pattern recognition receptors mainly expressing on
immune responsive cells. Toll-like receptors (TLRs)” are an example of pattern
recognition receptors, and TLR family members are conserved among mammals.

Mechanisms of Lymphocyte Activation and Immune Regulation X

Author: Sudhir Gupta

Publisher: Springer Science & Business Media

ISBN: 0387241809

Page: 163

View: 526

This volume is edited by Dr. Sudhir Gupta, internationally recognized expert in Immunology, Professor of Medicine, Pathology, Microbiology and Molecular Genetics. Topics include toll receptors, dendritic cells, NK cells, and complement receptors.

Toll Like Receptors TLRs and Innate Immunity

via protein receptor/nucleic acid ligand interactions is crucial for maintaining the
integrity of the genome and for survival. A number of pattern recognition
receptors (PRRs) have evolved that take part in nucleic acid recognition. In
general ...

Toll Like Receptors  TLRs  and Innate Immunity

Author: Stefan Bauer

Publisher: Springer Science & Business Media

ISBN: 9783540721673

Page: 240

View: 665

Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Target Pattern Recognition in Innate Immunity

At the frontlines of these responses, are a diverse group of pattern recognition
receptors that recognize pathogen associated ... genome has been sequenced,
which also expedites identification of genes and comparative genomics analyses
.

Target Pattern Recognition in Innate Immunity

Author: Uday Kishore

Publisher: Springer Science & Business Media

ISBN: 9781441909015

Page: 202

View: 174

Target pattern recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells. This is an area that has been very actively researched, over approximately the past 12 years, and therefore this volume provides a timely comprehensive, and up to date, summary of the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events. The Toll-like receptors, first described in Drosophila and now well-characterised on human cells, provide an excellent demonstration of the wide range of different microbial products recognised by this family of receptors and of the signalling pathways which are triggered thus leading to induction of inflammatory cytokines and the activation of genes producing antimicrobial products. In addition, several cell surface proteins involved in target pattern recognition have been described on the surfaces of macrophages (macrophage mannose receptor and macrophage scavenger receptors), and on dendritic cells (DEC205), and to be involved with the uptake and clearance of whole microorganisms and polyanioic ligands. Pattern recognition is also utilised by intracellular receptors, with NOD-like receptors in the cytosol recognizing microbial molecules and activating the production of inflammatory cytokines or pathways that induce the production of inflammatory molecules. Secreted proteins, such as the pentraxins, which includes the acute phase reacting, C-reactive protein (CRP) and serum amyloid protein (SAP), and the collectins (mannan binding lectin, lung surfactant protein A and D) and ficolins can also readily recruit killing and clearance systems. Indeed, the serum complement system, which is one of the major defence systems in the bloodstream, is efficiently activated by CR P on its binding to the phosphocholine groups of microbial phospholipids—and the subsequent interaction of the bound CR P with C1q—to give classical pathway activation, or MBL, or ficolin, binding to arrays of mannose or N-acetyl-glucosamine residues, respectively, on the surfaces of microorganisms—to give lectin pathway activation. Also, in addition to the activation and clearance events associated with complement activation by some of the secreted pattern recognition receptors, it is accepted that all these pattern recognition receptors can generally accelerate the uptake and clearance of microbes via phagocytic cells. In view of the growing interest in the cross-talk between innate and adaptive immunity, a thorough understanding of the initial recognition and triggering events, mediated via innate immune receptors, as addressed in this volume, is clearly very useful in helping to also fully understand the mechanisms of activation and control of the adaptive immune system—and to allow a full assessment of the relative roles played by innate immunity and adaptive immunity against a particular infection in higher organisms.

Insect Infection and Immunity

Nature Genetics 36, 240–246. Ochiai, M. and Ashida, M. (1999) A pattern
recognition protein for peptidoglycan. ... (2002) Functional genomic analysis of
phagocytosis and identification of a Drosophila receptor for E. coli. Nature 416,
644–648.

Insect Infection and Immunity

Author: Jens Rolff

Publisher: OUP Oxford

ISBN: 0191579149

Page: 272

View: 545

Under continual attack from both microbial pathogens and multicellular parasites, insects must cope with immune challenges every day of their lives. However, this has not prevented them from becoming the most successful group of animals on the planet. Insects possess highly-developed innate immune systems which have been fine-tuned by an arms race with pathogens spanning hundreds of millions of years of evolutionary history. Recent discoveries are revealing both an unexpected degree of specificity and an indication of immunological memory - the functional hallmark of vertebrate immunity. The study of insect immune systems has accelerated rapidly in recent years and is now becoming an important interdisciplinary field. Furthermore, insects are a phenomenally rich and diverse source of antimicrobial chemicals. Some of these are already being seriously considered as potential therapeutic agents to control microbes such as MRSA. Despite a burgeoning interest in the field, this is the first book to provide a coherent synthesis and is clearly structured around two broadly themed sections: mechanisms of immunity and evolutionary ecology. This novel text adopts an interdisciplinary and concept-driven approach, integrating insights from immunology, molecular biology, ecology, evolutionary biology, parasitology, and epidemiology. It features contributions from an international team of leading experts. Insect Infection and Immunity is suitable for both graduate students and researchers interested in insect immunity from either an evolutionary, genetical, physiological or molecular perspective. Due to its interdisciplinary and concept-driven approach, it will also appeal to a broader audience of immunologists, parasitologists and evolutionary biologists requiring a concise overview.

Genome Research

bre ise 1 ܘܢ ܐ Insights from the amphioxus genome on the origin of vertebrate.
diversified genes that contain ... IRFs : Master regulators of signalling by Toll - like
receptors and cytosolic pattern - recognition receptors . Nat . Rev. Immunol .

Genome Research

Author:

Publisher:

ISBN:

Page:

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Pediatric Critical Care E Book

For example, gene polymorphisms of TLR-2, the primary pattern recognition
receptor for gram-positive bacteria, have ... The first publication involving genome
-wide expression patterns in pediatric septic shock consisted of 42 children with ...

Pediatric Critical Care E Book

Author: Jerry J. Zimmerman

Publisher: Elsevier Health Sciences

ISBN: 0323081703

Page: 1776

View: 638

Provide the latest in superior quality care for critically ill children with the full-color, updated 4th Edition of Fuhrman and Zimmerman’s Pediatric Critical Care. In print, and now online, Drs. Bradley P. Fuhrman and Jerry J. Zimmerman use a comprehensive, organ-systems approach to help you manage a full range of disease entities. Get up-to-the-minute knowledge of topics such as acute lung injury, multiple organ dysfunction syndrome, and more. Implement new clinical techniques and diagnostic tests, weigh the varying perspectives of six associate editors with expertise in the field, reference 1,000+ illustrations to aid diagnosis, and keep sharp with online access to board-style review questions. This definitive title will ensure that you consistently deliver the very best intensive care to your pediatric patients. Focus on the development, function, and treatment of a wide range of disease entities with the text’s clear, logical, organ-system approach. Keep all members of the pediatric ICU team up to date with coverage of topics particularly relevant to their responsibilities. Keep current with the latest developments in palliative care, mass casualty/epidemic disease, acute respiratory failure, non-invasive ventilation, neurocritical care, neuroimaging, hypoxic-ischemic encephalopathy, stroke and intracerebral hemorrhage, systemic inflammatory response syndrome, acute lung injury, multiple organ dysfunction syndrome, and much more. Quickly find the information you need with sections newly reorganized for easier access. Gain the perspectives of six expert associate editors on all the new developments in the field. Understand complex concepts quickly and conclusively with a brand new full-color format and more than 1,000 illustrations. Search the full text, download the image library, and access online board review questions targeting every relevant topic, all at www.expertconsult.com.

Effectors in Plant Microbe Interactions

See PEL proteins Pathogen-related proteins (PR), 21 Pattern recognition, 3–25
Pattern recognition receptors (PRR), 3, 33 BAK1 in regulation of, 12 chimeric
receptor analysis for, 9 genetics in identification of, 7 MAMP/DAMP binding sites
with, ...

Effectors in Plant Microbe Interactions

Author: Francis Martin

Publisher: John Wiley & Sons

ISBN: 0470958227

Page: 444

View: 725

Plants and microbes interact in a complex relationship that canhave both harmful and beneficial impacts on both plant andmicrobial communities. Effectors, secreted microbial molecules thatalter plant processes and facilitate colonization, are central tounderstanding the complicated interplay between plants andmicrobes. Effectors in Plant-Microbe Interactionsunlocks the molecular basis of this important class of microbialmolecules and describes their diverse and complex interactions withhost plants. Effectors in Plant Microbe Interactions is divided intofive sections that take stock of the current knowledge on effectorsof plant-associated organisms. Coverage ranges from the impact ofbacterial, fungal and oomycete effectors on plant immunity andhigh-throughput genomic analysis of effectors to the function andtrafficking of these microbial molecules. The final section looksat effectors secreted by other eukaryotic microbes that are thefocus of current and future research efforts. Written by leading international experts in plant-microbeinteractions, Effectors in Plant Microbe Interactions, willbe an essential volume for plant biologists, microbiologists,pathologists, and geneticists.

Journal of Experimental Biology

01066 - Review - Innate immunity in the malaria vector Anopheles gambiae :
comparative and functional genomics Mike ... In this context , putative pattern (
vaccines ) , prophylaxis / treatment ( antimalarial drugs ) and recognition
receptors of ...

Journal of Experimental Biology

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7th International Conference on Practical Applications of Computational Biology Bioinformatics

Molecular mechanisms of plant-pathogen interaction have been studied
thoroughly because of its importance for crop production and ... have provided
the opportunity to analyze genomic data publicly available in databases. ... Plant
immunity depends on the recognition of conserved Microbial Associated
Molecular Patterns (MAMPs) or strain-specific effectors by Pattern Recognition
Receptors (PPRs) or ...

7th International Conference on Practical Applications of Computational Biology   Bioinformatics

Author: Mohd Saberi Mohamad

Publisher: Springer Science & Business Media

ISBN: 3319005782

Page: 153

View: 311

The growth in the Bioinformatics and Computational Biology fields over the last few years has been remarkable and the trend is to increase its pace. In fact, the need for computational techniques that can efficiently handle the huge amounts of data produced by the new experimental techniques in Biology is still increasing driven by new advances in Next Generation Sequencing, several types of the so called omics data and image acquisition, just to name a few. The analysis of the datasets that produces and its integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Within this scenario of increasing data availability, Systems Biology has also been emerging as an alternative to the reductionist view that dominated biological research in the last decades. Indeed, Biology is more and more a science of information requiring tools from the computational sciences. In the last few years, we have seen the surge of a new generation of interdisciplinary scientists that have a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. PACBB‘13 hopes to contribute to this effort promoting this fruitful interaction. PACBB'13 technical program included 19 papers from a submission pool of 32 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Therefore, the conference will certainly have promoted the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists). The scientific content will certainly be challenging and will promote the improvement of the work that is being developed by each of the participants.

The Journal of Cell Biology

Toll - like receptor 2 functions as a pattern recognition receptor for diverse
bacterial products . J . Biol . Chem . ... and R . A . Ezekowitz . 2002 . Functional
genomic analysis of phagocytosis and identification of a Drosophila receptor for
E ...

The Journal of Cell Biology

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ISBN:

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No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

Avian Genomics in Evolution Agriculture and Health

Jacqueline Smith, Indrajit Nanda. H5N1 influenza , which are universally lethal to
chickens . ceptors and pattern recognition receptors at the interface of We have
also examined the expression of cytokines and in- pathogen - host interactions ...

Avian Genomics in Evolution  Agriculture and Health

Author: Jacqueline Smith

Publisher: S Karger Ag

ISBN:

Page: 404

View: 547

This special issue highlights current research in avian genomics. Most contributions relate to the chicken as the model bird species, but advances in the genomics of turkey, duck and other birds are also presented. With a mixture of review articles and original research papers, this publication illustrates how advances in avian genomics have impacted on a wide range of disciplines such as cytogenetics, genetics, immunology, evolution and development. The many resources that are now available to researchers are also described. The knowledge gained from the avian genomes is not just applicable to bird species but offers a useful comparative tool that helps further research across many species. The study of the avian genomes is also shown to play an important role in the fields of agriculture and human health, e.g. in respect to avian influenza. Well edited and up-to-date, this issue is recommended reading to scientists working in any of the above-mentioned fields of avian research.