The Telomerase Revolution

The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.

The Telomerase Revolution

Author: Michael Fossel

Publisher: BenBella Books, Inc.

ISBN: 1941631703

Page: 256

View: 983

One of Wall Street Journal’s "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell’s ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body’s trillions of cells. But some of our cells don’t age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 1999

BIOLOGY OF AGING Advances in basic biology have fueled a revolution in aging
research . A notable example ... Major new advances have been made in
understanding the role of telomeres and telomerase in aging and cancer .
Telomeres ...

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 1999

Author: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies

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Chasing Methuselah

204 Her co-authored book entitled The Telomere Effect: A Revolutionary
Approach to Living Younger, Healthier, Longer (2017), joins a rapidly expanding
list of recent offerings with titles such as The Telomerase Revolution, The
Telomere ...

Chasing Methuselah

Author: Todd T. W. Daly

Publisher: Wipf and Stock Publishers

ISBN: 153269802X

Page: 324

View: 148

The quest to live much longer has moved from legend to the laboratory. Recent breakthroughs in genetics and pharmacology have put humanity on the precipice of slowing down human aging to extend the healthy life span. The promise of longer, healthier life is enormously attractive, and poses several challenging questions for Christians. Who wouldn't want to live 120 years or more before dying quickly? How do we make sense of human aging in light of Jesus' invitation to daily take up our crosses with the promise of the resurrection to come? Is there anything wrong with manipulating our bodies technologically to live longer? If so, how long is too long? Should aging itself be treated as a disease? In Chasing Methuselah, Todd Daly examines the modern biomedical anti-aging project from a Christian perspective, drawing on the ancient wisdom of the Desert Fathers, who believed that the incarnation opened a way for human life to regain the longevity of Adam and the biblical patriarchs through prayer and fasting. Daly balances these insights with the christological anthropology of Karl Barth, discussing the implications for human finitude, fear of death, and the use of anti-aging technology, weaving a path between outright condemnation and uncritical enthusiasm.

In Vivo

3 Banks DA , Fossel M : Telomeres , cancer , and aging , altering the human
lifespan . JAMA 278 ... Vaziri H : Extension of Life Span in Normal Human Cells
by Telomerase Activation : A Revolution in Culhlral Senescence . Journal of Anti
 ...

In Vivo

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The Personalized Medicine Revolution

As a result, the study of telomeres has become a central feature of aging
research because it suggests that the reason you get old and die is because your
telomeres get shorter as you get older, resulting in more senescent cells that don'
t ...

The Personalized Medicine Revolution

Author: Pieter Cullis

Publisher: Greystone Books

ISBN: 1771640391

Page: 176

View: 491

Every one of us is unique. With recent advances in technology, we now know that that statement is more true that ever: we are each individuals, right down to a molecular level — a one-of-a-kind combination of genes, proteins, and metabolism. So why does healthcare still take a one-size-fits-all approach? The same methods are used on everyone to diagnose illness, and the same drugs are used to treat it — despite the fact that those methods and treatments are not effective for everyone and are even harmful for some. Shouldn’t our medicine be tailored to our differences? The Personalized Medicine Revolution explores recent advances in genomics, the study of the human genome — as well as its cousins proteomics, metabolomics, microbiomics, and the like — and explains how technology is even now changing the way medicine is delivered. Along the way, it takes the reader through the five critical healthcare areas that will be transformed most radically by personalized medicine — prediction, prevention, diagnosis, treatment, and monitoring — and examines the practical and ethical issues involved. Finally, it details how readers can use personalized medicine to take charge of their own health and build a stronger and safer medical system.

Russ Coile s Health Care Forecast

GenomOn the far side of the technology , new genetic discov ics offers the
possibility of treating the root ( genetic ) eries hold out the promise of “ anti - aging
" " The Quiet Genetics Revolution : treatments one day . Isolation of telomerase ...

Russ Coile s Health Care Forecast

Author: Russell C. Coile

Publisher:

ISBN: 9780834218727

Page: 106

View: 489

Biotechnology and the Future of Society

reproduction , the fuse ( the telomere ) gets shorter and shorter , until it
disappears and the chromosome disintegrates . ... This new green revolution by
itself will not be able to feed the growing populations in the Third World , but it
may help to ...

Biotechnology and the Future of Society

Author: Emirates Center for Strategic Studies & Research

Publisher: I.B. Tauris

ISBN: 9789948005087

Page: 320

View: 220

Breakthroughs in biotechnology are redefining the very concept of life, transforming society and presenting unprecedented opportunities and challenges: will human genome sequencing help to treat genetic diseases and indefinitely prolong life? Can nature's workshops inspire superior biomaterials that transform industries? Will genetically modified super crops feed a hungry world? With biotechnology set to be the driving force of the twenty-first century, mastery of the life sciences will be the key to wealth generation and economic ascendancy. Can the Arab world regain its past supremacy in these fields? Can it benefit from the biotech revolution while avoiding its perils? These essays examine the complex ethical, legal and social issues raised by the biotech revolution that need to be resolved by governments and decision makers.

Life Itself

This DNA coding , called a telomere , is not the recipe of a gene , nor a regulatory
sequence . It is there to compensate for what might be called ... die if they are
simply deprived of telomerase . The researchers were able to kill REVOLUTION
241.

Life Itself

Author: Boyce Rensberger

Publisher: Oxford University Press, USA

ISBN:

Page: 290

View: 263

Brings readers to the frontlines of cell research with some of the preeminent investigators in molecular, cellular, and developmental biology, offering information on the nature of life, the body's immune system, illness, and more. UP.

The Scientist

19 Courtesy of Seton Scientific CULTURAL REVOLUTION : Mycoplasma testing
kits and services . ..21 PATENTING ... Thomas R. Cech of the University of
Colorado Health Sciences Center discuss the telomerase enzyme in cancer
formation .

The Scientist

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New Scientist

And it was Geron that identified the gene for telomerase , the enzyme that
rebuilds the telomeres at the ends of ... prophet and wheeler" echo of the big
bang " in 1965 . things , that the universe is 13.7 billion dealer of the biotech
revolution .

New Scientist

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Visions

If we can neutralize telomerase , we can make the cells mortal again , just like
other cells . No one knows precisely which therapy will be most effective against
cancer . But the point is that the biomolecular revolution has now cracked the ...

Visions

Author: Michio Kaku

Publisher: Oxford University Press, USA

ISBN:

Page: 403

View: 941

In this text, physicist Michio Kaku looks to this future and guides the reader through the science of the next century. His vision of this future is based on the pioneering efforts by theoreticians and the current laboratory research. Dr Kaku asserts that, using today's knowledge, we can confidently predict the direction of science through the next century.

Men s Health the Hormone Revolution

Besides the telomerase enzyme and the chemical wear - and - tear caused by
free oxygen radicals , are there any other mechanisms controlling the fate of cells
? Can this biophysical process be influenced by hormones in a way that would ...

Men s Health   the Hormone Revolution

Author: Siegfried Meryn

Publisher: Richmond Hill, ON : NDE Pub.

ISBN:

Page: 318

View: 139

This controversial guide explores how aging affects a man's life & how hormones play a pivotal role in mental fitness, stress, mid-life crises, & virility.

Still from the Heart

Our Posthuman Nature , Consequences of Biotechnology Revolution . London :
Profile Books Ltd . , 2002 . Geron . “ Activation of Telomerase in Normal Human
Cells Extends Their Life - span . ” 2004 . http : / / www . geron . com / showpage ...

Still from the Heart

Author: Tamerlane R. Lana

Publisher:

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Page: 639

View: 696

Genetics Abstracts

Accelerated telomere loss has been proposed to be a factor leading to end -
stage organ failure in chronic diseases of high ... The new genetics , emerging as
a scientific revolution , is reinforcing the biological theories which accounts for ...

Genetics Abstracts

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Mutants

323 Telomerase - mutant humans . Hutchinson - Gilford syndrome ( progeria ) (
176670 ) is caused by a mutation in the gene encoding Lamin A and C . 323 In
the last ten years there has been a revolution . See Kenyon et al . ( 1993 ) for a ...

Mutants

Author: Armand Marie Leroi

Publisher: Penguin Group USA

ISBN:

Page: 431

View: 595

A study of congenital disease and some of the famous individuals whose lives were affected by congenital abnormalities offers insight to mankind's evolutionary history.